HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	37059091, 19596235
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 1834
+	Hs
		598120 FLNA_HUMAN (1-2647): 0: 2776: 100.00		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54
+	Hs
		261264 FLNB_HUMAN (28-2647): 0: 2710: 69.63		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54
+	Hs
		211611 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		211525 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79
+	Hs
		963292 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		ANK2_HUMAN (1147-1751): 8.46e-11: 69.7: 10.18
+	Ce
		184367 Q23158_CAEEL (23-268): 6.21e-105: 362: 32.93		O17084_CAEEL (909-1574): 2.13e-14: 81.6: 9.82
+	Dm
		1364771 FLNA_DROME (2539-2646): 9.6e-12: 73.5: 28.57		Q9VXR3_DROME (1285-1823): 8.57e-28: 125: 11.46