HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: MY18A (Q92614)
Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)
Gene: MYO18A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005802 - trans-Golgi network GO:0016020 - membrane GO:0043066 - negative regulation of apoptotic process and 1 others more... GO:0051015 - actin filament binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 2054
+	Hs
		261303 FLNB_HUMAN (28-2647): 0: 2710: 69.63		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		597985 FLNA_HUMAN (1-2647): 0: 2776: 100.00		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		261212 FLNB_HUMAN (28-2647): 0: 2710: 69.63		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		598338 FLNA_HUMAN (1-2647): 0: 2776: 100.00		MYO5C_HUMAN (1119-1615): 4.36e-24: 113: 12.21
+	Hs
		597987 FLNA_HUMAN (1-2647): 0: 2776: 100.00		MYH11_HUMAN (1684-2053): 3.04e-19: 97.5: 15.00
+	Hs
		598391 FLNA_HUMAN (1-2647): 0: 2776: 100.00		MYO5A_HUMAN (1789-2053): 7.86e-13: 76.7: 12.84
+	Hs
		963381 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		211632 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		724781 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		521484 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		211515 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		963431 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		MYO5C_HUMAN (1119-1615): 4.36e-24: 113: 12.21
+	Hs
		211671 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		MYO5C_HUMAN (1119-1615): 4.36e-24: 113: 12.21
+	Dm
		90591 E1JGS7_DROME (500-1263): 5.3e-88: 323: 23.04		MYSN_DROME (1218-1932): 2.19e-38: 160: 23.06
+	Dm
		404218 ACTN_DROME (22-268): 2.24e-102: 354: 33.47		MYSA_DROME (1659-2054): 1.99e-22: 108: 12.50
+	Dm
		1303393 FLNA_DROME (2539-2646): 9.6e-12: 73.5: 28.57		MYSN_DROME (1218-1932): 2.19e-38: 160: 23.06