HitPredict

Interactor 1: NF1 (P21359)
Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated]
Gene: NF1

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007519 - skeletal muscle tissue development GO:0030036 - actin cytoskeleton organization and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2839 Hs			1 193
+	Hs
		598457 NF1_HUMAN (1-2839): 0: 4435: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		598452 NF1_HUMAN (1-2839): 0: 4435: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		598451 NF1_HUMAN (1-2839): 0: 4435: 100.00		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		598456 NF1_HUMAN (1-2839): 0: 4435: 100.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		925282 RASA3_HUMAN (1195-1654): 2.34e-115: 390: 22.83		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		894015 RASA3_HUMAN (1195-1654): 2.34e-115: 390: 22.83		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545380 RASA3_HUMAN (1195-1654): 2.34e-115: 390: 22.83		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		892375 RASA3_HUMAN (1195-1654): 2.34e-115: 390: 22.83		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		120440 RASA3_HUMAN (1195-1654): 2.34e-115: 390: 22.83		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		901032 NGAP_HUMAN (1171-1598): 4.27e-93: 332: 22.00		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925715 NGAP_HUMAN (1171-1598): 4.27e-93: 332: 22.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		436564 NGAP_HUMAN (1171-1598): 4.27e-93: 332: 22.00		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		951447 NGAP_HUMAN (1171-1598): 4.27e-93: 332: 22.00		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		894568 NGAP_HUMAN (1171-1598): 4.27e-93: 332: 22.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545691 NGAP_HUMAN (1171-1598): 4.27e-93: 332: 22.00		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		545434 DAB2P_HUMAN (1189-1556): 3.79e-91: 327: 25.14		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		892671 NGAP_HUMAN (1171-1598): 4.27e-93: 332: 22.00		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		916057 NGAP_HUMAN (1171-1598): 4.27e-93: 332: 22.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		892426 DAB2P_HUMAN (1189-1556): 3.79e-91: 327: 25.14		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		120704 NGAP_HUMAN (1171-1598): 4.27e-93: 332: 22.00		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98