HitPredict

Interactor 1: NF1 (P21359)
Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated]
Gene: NF1

Interactor 2: KCC2B (Q13554)
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Gene: CAMK2B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048169 - regulation of long-term neuronal synaptic plasticity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 2839 Hs			1 666
+	Rn
		956839 NF1_RAT (1-2839): 0: 4418: 97.47		CSKP_RAT (10-308): 1.29e-81: 278: 46.73
+	Hs
		598473 NF1_HUMAN (1-2839): 0: 4435: 100.00		KCC2G_HUMAN (381-666): 5.77e-58: 206: 50.00
+	Hs
		598474 NF1_HUMAN (1-2839): 0: 4435: 100.00		KCC2D_HUMAN (507-666): 1.24e-53: 193: 71.25
+	Hs
		1038915 SYGP1_HUMAN (1187-1585): 1.47e-88: 321: 18.91		KCC2B_HUMAN (1-666): 0: 710: 100.00
+	Mm
		99917 SYGP1_MOUSE (1187-1585): 7.71e-88: 319: 18.91		KCC2B_MOUSE (436-666): 3.97e-59: 209: 60.94
+	Hs
		1039019 SYGP1_HUMAN (1187-1585): 1.47e-88: 321: 18.91		KCC2G_HUMAN (381-666): 5.77e-58: 206: 50.00
+	Hs
		1039152 SYGP1_HUMAN (1187-1585): 1.47e-88: 321: 18.91		KCC2D_HUMAN (507-666): 1.24e-53: 193: 71.25
+	Mm
		99901 SYGP1_MOUSE (1187-1585): 7.71e-88: 319: 18.91		KCC2A_MOUSE (493-663): 1.7e-50: 184: 61.40
+	Rn
		88547 D3ZCL8_RAT (1187-1585): 3.41e-87: 316: 19.15		KCC2A_RAT (493-663): 1.7e-50: 184: 61.40
+	Mm
		515255 IQGA1_MOUSE (1172-1597): 6.95e-79: 293: 16.08		KCC2A_MOUSE (493-663): 1.7e-50: 184: 61.40
+	Hs
		809299 IQGA1_HUMAN (1241-1559): 7.46e-49: 195: 19.84		KCC2G_HUMAN (381-666): 5.77e-58: 206: 50.00