Interactor 1: NF1 (P21359)
Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated]
Gene: NF1

Interactor 2: SPRE1 (Q7Z699)
Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)
Gene: SPRED1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 0.60 0.653

The method score is based on:

Property Details
Experiments 27313208, 26635368
Identification Methods affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006469 - negative regulation of protein kinase activity
GO:0016525 - negative regulation of angiogenesis
and 1 others

more...

Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 2839
Hs

1 444
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
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+ Mm
+ Dm
+ Hs

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Last updated: 15 Jul 2024