HitPredict

Interactor 1: S1PR1 (P21453)
Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)
Gene: S1PR1

Interactor 2: AT12A (P54707)
Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump)
Gene: ATP12A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 382 Hs			1 1039
+	Hs
		328306 S1PR4_HUMAN (1-329): 2.24e-81: 255: 39.76		AT1A3_HUMAN (42-1039): 0: 1018: 65.03
+	Hs
		530828 S1PR1_HUMAN (1-382): 1.84e-80: 253: 100.00		AT1A3_HUMAN (42-1039): 0: 1018: 65.03
+	Hs
		392982 ADRB2_HUMAN (14-347): 8.85e-70: 226: 17.08		AT1A1_HUMAN (23-1039): 0: 1030: 64.52
+	Hs
		328317 S1PR4_HUMAN (1-329): 2.24e-81: 255: 39.76		AT12A_HUMAN (1-1039): 0: 994: 100.00
+	Mm
		677396 SSR3_MOUSE (1-343): 1.19e-64: 213: 18.08		AT1A1_MOUSE (23-1039): 0: 1034: 64.13
+	Hs
		530839 NK3R_HUMAN (11-365): 2.2e-65: 216: 18.08		AT1A3_HUMAN (42-1039): 0: 1018: 65.03
+	Hs
		530844 OPRX_HUMAN (10-344): 2.01e-65: 214: 14.83		AT1A3_HUMAN (42-1039): 0: 1018: 65.03
+	Mm
		677315 SSR3_MOUSE (1-343): 1.19e-64: 213: 18.08		AT1A3_MOUSE (43-1039): 0: 1017: 64.90
+	Hs
		208450 OX2R_HUMAN (6-372): 1.35e-67: 221: 16.02		AT12A_HUMAN (1-1039): 0: 994: 100.00
+	Mm
		677316 SSR3_MOUSE (1-343): 1.19e-64: 213: 18.08		AT1A2_MOUSE (47-1039): 0: 1001: 65.76
+	Hs
		666302 NK3R_HUMAN (11-365): 2.2e-65: 216: 18.08		AT12A_HUMAN (1-1039): 0: 994: 100.00
+	Hs
		781050 OPRX_HUMAN (10-344): 2.01e-65: 214: 14.83		AT12A_HUMAN (1-1039): 0: 994: 100.00
+	Hs
		163912 LPAR1_HUMAN (23-342): 6.22e-89: 274: 38.51		AT2A1_HUMAN (58-1028): 0: 761: 26.32
+	Hs
		328366 S1PR4_HUMAN (1-329): 2.24e-81: 255: 39.76		AT2A3_HUMAN (58-1036): 0: 761: 26.50
+	Hs
		598761 S1PR1_HUMAN (1-382): 1.84e-80: 253: 100.00		AT2A3_HUMAN (58-1036): 0: 761: 26.50
+	Hs
		1274529 LPAR2_HUMAN (23-365): 5.55e-76: 240: 34.88		AT2A3_HUMAN (58-1036): 0: 761: 26.50
+	Hs
		428908 ADRB2_HUMAN (14-347): 8.85e-70: 226: 17.08		AT2A2_HUMAN (57-1028): 0: 762: 26.22
+	Hs
		561507 CNR2_HUMAN (47-367): 1.48e-66: 216: 25.23		AT2A2_HUMAN (57-1028): 0: 762: 26.22
+	Hs
		561517 OPRD_HUMAN (10-361): 3.09e-66: 216: 17.63		AT2A2_HUMAN (57-1028): 0: 762: 26.22
+	Mm
		223150 SSR3_MOUSE (1-343): 1.19e-64: 213: 18.08		AT2A2_MOUSE (57-1028): 0: 760: 26.22