HitPredict

Interactor 1: S1PR1 (P21453)
Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)
Gene: S1PR1

Interactor 2: TNPO3 (Q9Y5L0)
Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)
Gene: TNPO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 382 Hs			1 923
+	Hs
		328421 S1PR4_HUMAN (1-329): 2.24e-81: 255: 39.76		TNPO3_HUMAN (1-923): 0: 657: 100.00
+	Hs
		723121 OPRM_HUMAN (3-375): 1.25e-67: 220: 15.45		TNPO3_HUMAN (1-923): 0: 657: 100.00
+	Hs
		162440 CNR2_HUMAN (47-367): 1.48e-66: 216: 25.23		XPO1_HUMAN (3-920): 6.76e-151: 475: 12.37
+	Hs
		297159 OPRM_HUMAN (3-375): 1.25e-67: 220: 15.45		IPO13_HUMAN (5-923): 2.1e-143: 452: 21.02
+	Hs
		312181 S1PR1_HUMAN (1-382): 1.84e-80: 253: 100.00		IPO7_HUMAN (13-813): 8.63e-101: 340: 11.63
+	Hs
		207866 S1PR4_HUMAN (1-329): 2.24e-81: 255: 39.76		XPOT_HUMAN (12-770): 1.76e-93: 318: 15.10
+	Hs
		155526 S1PR1_HUMAN (1-382): 1.84e-80: 253: 100.00		TNPO2_HUMAN (68-784): 3.33e-92: 313: 12.26
+	Hs
		178087 S1PR4_HUMAN (1-329): 2.24e-81: 255: 39.76		IPO8_HUMAN (10-813): 5.2e-89: 307: 9.92
+	Hs
		178109 S1PR1_HUMAN (1-382): 1.84e-80: 253: 100.00		IPO8_HUMAN (10-813): 5.2e-89: 307: 9.92
+	Hs
		664375 AA2BR_HUMAN (53-327): 2.59e-13: 72: 23.73		XPO5_HUMAN (9-614): 3.04e-22: 105: 14.21