HitPredict

Interactor 1: SINA (P21461)
E3 ubiquitin-protein ligase sina (EC 2.3.2.27) (RING-type E3 ubiquitin transferase sina) (Seven in absentia protein)
Gene: SINA

Interactor 2: Q8IQ53 (Q8IQ53)
GEO11416p1 (MIP16420p) (Ubiquitin-conjugating enzyme variant 1A, isoform B)
Gene: Uev1A

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	37061542
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 314 Dm			1 103
+	Dm
		598811 SINA_DROME (1-314): 9.1e-113: 330: 100.00		UBCD1_DROME (2-103): 1.18e-49: 155: 23.53
+	Hs
		1216737 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2D4_HUMAN (2-103): 2.63e-49: 154: 22.55
+	Hs
		895842 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2D3_HUMAN (2-103): 3.13e-49: 154: 21.57
+	Hs
		919778 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2D2_HUMAN (2-103): 2.93e-49: 154: 21.57
+	Hs
		1216686 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2E2_HUMAN (2-103): 4.55e-48: 153: 21.57
+	Hs
		849364 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2D1_HUMAN (2-103): 1.02e-48: 153: 21.57
+	Hs
		1216680 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2E3_HUMAN (2-103): 7.86e-48: 152: 21.57
+	Dm
		598891 SINA_DROME (1-314): 9.1e-113: 330: 100.00		Q9VRL1_DROME (1-103): 3.05e-45: 144: 100.00
+	Hs
		1079002 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2V2_HUMAN (1-103): 2.04e-46: 147: 61.17
+	Hs
		199103 SIAH2_HUMAN (64-312): 1.14e-100: 300: 81.60		UB2D3_HUMAN (2-103): 3.13e-49: 154: 21.57
+	Hs
		199105 SIAH2_HUMAN (64-312): 1.14e-100: 300: 81.60		UB2D2_HUMAN (2-103): 2.93e-49: 154: 21.57
+	Hs
		199099 SIAH2_HUMAN (64-312): 1.14e-100: 300: 81.60		UB2D1_HUMAN (2-103): 1.02e-48: 153: 21.57
+	Dm
		639400 SINAL_DROME (8-314): 4.64e-98: 294: 47.88		UBCD1_DROME (2-103): 1.18e-49: 155: 23.53
+	Hs
		199116 SIAH2_HUMAN (64-312): 1.14e-100: 300: 81.60		UB2V2_HUMAN (1-103): 2.04e-46: 147: 61.17
+	Dm
		854568 SINAL_DROME (8-314): 4.64e-98: 294: 47.88		UBCD2_DROME (2-103): 6.78e-47: 151: 22.55
+	At
		1323941 SINL7_ARATH (30-270): 8.69e-51: 171: 21.69		UEV1D_ARATH (1-103): 4.77e-48: 151: 44.66
+	Hs
		895838 TRI50_HUMAN (65-235): 7.73e-39: 144: 17.62		UB2D3_HUMAN (2-103): 3.13e-49: 154: 21.57
+	Hs
		919773 TRI50_HUMAN (65-235): 7.73e-39: 144: 17.62		UB2D2_HUMAN (2-103): 2.93e-49: 154: 21.57
+	Hs
		849360 TRI50_HUMAN (65-235): 7.73e-39: 144: 17.62		UB2D1_HUMAN (2-103): 1.02e-48: 153: 21.57
+	Hs
		1204900 TRI50_HUMAN (65-235): 7.73e-39: 144: 17.62		UB2E3_HUMAN (2-103): 7.86e-48: 152: 21.57