HitPredict

Interactor 1: SINA (P21461)
E3 ubiquitin-protein ligase sina (EC 2.3.2.27) (RING-type E3 ubiquitin transferase sina) (Seven in absentia protein)
Gene: SINA

Interactor 2: Q9VJS5 (Q9VJS5)
AT16033p (GEO08666p1)
Gene: DmelCG3473

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	37061542, unassigned1513
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 314 Dm			1 151
+	Dm
		598811 SINA_DROME (1-314): 9.1e-113: 330: 100.00		UBCD1_DROME (4-149): 1.15e-79: 233: 49.32
+	Hs
		1216737 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2D4_HUMAN (4-149): 9e-81: 236: 48.63
+	Hs
		849364 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2D1_HUMAN (4-149): 3.18e-80: 235: 47.26
+	Hs
		919778 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2D2_HUMAN (4-149): 8.62e-80: 233: 47.95
+	Hs
		895842 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2D3_HUMAN (4-149): 8.9e-79: 231: 47.26
+	Hs
		1216686 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2E2_HUMAN (1-149): 2.93e-75: 224: 43.62
+	Hs
		1216680 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UB2E3_HUMAN (1-149): 9.99e-75: 223: 43.62
+	Dm
		598812 SINA_DROME (1-314): 9.1e-113: 330: 100.00		UBE2N_DROME (1-151): 1.75e-72: 215: 80.80
+	Hs
		896488 SIAH1_HUMAN (34-313): 1.69e-110: 323: 76.43		UBE2N_HUMAN (1-151): 7.36e-72: 214: 78.81
+	Hs
		199099 SIAH2_HUMAN (64-312): 1.14e-100: 300: 81.60		UB2D1_HUMAN (4-149): 3.18e-80: 235: 47.26
+	Hs
		199105 SIAH2_HUMAN (64-312): 1.14e-100: 300: 81.60		UB2D2_HUMAN (4-149): 8.62e-80: 233: 47.95
+	Hs
		199103 SIAH2_HUMAN (64-312): 1.14e-100: 300: 81.60		UB2D3_HUMAN (4-149): 8.9e-79: 231: 47.26
+	Dm
		639400 SINAL_DROME (8-314): 4.64e-98: 294: 47.88		UBCD1_DROME (4-149): 1.15e-79: 233: 49.32
+	Dm
		854568 SINAL_DROME (8-314): 4.64e-98: 294: 47.88		UBCD2_DROME (3-149): 5.87e-74: 222: 43.54
+	Hs
		199104 SIAH2_HUMAN (64-312): 1.14e-100: 300: 81.60		UBE2N_HUMAN (1-151): 7.36e-72: 214: 78.81
+	Dm
		715099 SINAL_DROME (8-314): 4.64e-98: 294: 47.88		UBE2N_DROME (1-151): 1.75e-72: 215: 80.80
+	Dm
		1250208 SINAL_DROME (8-314): 4.64e-98: 294: 47.88		Q9VJS5_DROME (1-151): 1.67e-70: 210: 100.00
+	At
		1323937 SINL7_ARATH (30-270): 8.69e-51: 171: 21.69		UBC36_ARATH (2-148): 1e-76: 226: 72.11
+	Hs
		849360 TRI50_HUMAN (65-235): 7.73e-39: 144: 17.62		UB2D1_HUMAN (4-149): 3.18e-80: 235: 47.26
+	Hs
		851837 TRI50_HUMAN (65-235): 7.73e-39: 144: 17.62		UB2E1_HUMAN (1-149): 2.79e-73: 219: 42.95