HitPredict

Interactor 1: ZYG11 (P21541)
Early embryogenesis protein zyg-11
Gene: zyg-11

Interactor 2: CUL2 (Q17390)
Cullin-2 (CUL-2)
Gene: cul-2

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	21527776, 17304241, 17609115
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008595 - anterior/posterior axis specification, embryo GO:0031145 - anaphase-promoting complex-dependent catabolic process GO:0031462 - Cul2-RING ubiquitin ligase complex GO:0051759 - sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation GO:1902104 - positive regulation of metaphase/anaphase transition of meiotic cell cycle
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 799 Ce			1 791
+	Hs
		1041462 ZY11B_HUMAN (103-786): 0: 595: 29.83		CUL2_HUMAN (19-791): 0: 751: 42.78
+	Ce
		1088872 ZER1_CAEEL (145-773): 7.59e-165: 502: 23.77		CUL2_CAEEL (1-791): 0: 829: 100.00
+	Hs
		1041376 ZER1_HUMAN (152-781): 1.13e-163: 494: 23.04		CUL2_HUMAN (19-791): 0: 751: 42.78
+	Hs
		1043082 ZER1_HUMAN (152-781): 1.13e-163: 494: 23.04		CUL4A_HUMAN (18-791): 0: 741: 23.92
+	Ce
		1088863 ZER1_CAEEL (145-773): 7.59e-165: 502: 23.77		CUL1_CAEEL (18-791): 0: 706: 27.61
+	Ce
		1088876 Q9XTS0_CAEEL (15-741): 1.56e-108: 349: 18.44		CUL2_CAEEL (1-791): 0: 829: 100.00
+	Ce
		109334 H2KMM0_CAEEL (7-739): 7.83e-91: 307: 20.03		CUL2_CAEEL (1-791): 0: 829: 100.00