HitPredict

Interactor 1: TNAP3 (P21580)
Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37]
Gene: TNFAIP3

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045824 - negative regulation of innate immune response GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 790 Hs			1 248
+	Hs
		599644 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		599646 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		599616 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		599621 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		599643 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		599650 TNAP3_HUMAN (1-790): 0: 1520: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Mm
		1141361 TNAP3_MOUSE (1-790): 0: 1470: 88.10		1433B_MOUSE (1-239): 3.73e-99: 290: 68.62
+	Mm
		905339 TNAP3_MOUSE (1-790): 0: 1470: 88.10		1433G_MOUSE (1-242): 1.86e-98: 289: 65.16
+	Hs
		684378 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		910126 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		927626 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		647359 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		647132 OTU7A_HUMAN (43-294): 2.76e-94: 316: 36.40		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683442 OTU7B_HUMAN (39-299): 1.32e-98: 326: 37.37		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		683790 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		905220 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		904901 OTU7A_HUMAN (43-294): 2.76e-94: 316: 36.40		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		982591 ZRAN1_HUMAN (47-308): 4.61e-97: 318: 33.79		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		982313 OTU7A_HUMAN (43-294): 2.76e-94: 316: 36.40		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20