HitPredict

Interactor 1: TAF1 (P21675)
Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
Gene: TAF1

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

The method score is based on:

Property	Details
Experiments	9388200, 17237821
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000209 - protein polyubiquitination GO:0002039 - p53 binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 2 others more... GO:0006511 - ubiquitin-dependent protein catabolic process GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	1893
Hs

1	491

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024