HitPredict

Interactor 1: SIR1 (P21691)
Regulatory protein SIR1 (Heterochromatin protein SIR1) (Silent information regulator 1)
Gene: SIR1

Interactor 2: ORC1 (P54784)
Origin recognition complex subunit 1 (Origin recognition complex 120 kDa subunit)
Gene: ORC1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	8622770, 12198162, 14701749, 9872946, 15932939, 19029247, 15937111
Identification Methods	two hybrid, pull down, affinity chromatography technology, x-ray crystallography
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	BAH~Sir1
Common GO terms	GO:0003682 - chromatin binding GO:0030466 - silent mating-type cassette heterochromatin formation
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1 654 Sc			1 914
+	Sc
		416281 SIR1_YEAST (1-654): 0: 1360: 100.00		SIR3_YEAST (1-914): 0: 587: 26.50