HitPredict

Interactor 1: EPHA1 (P21709)
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Gene: EPHA1

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 1116
+	Hs
		1072602 EPHA7_HUMAN (2-975): 0: 1117: 43.22		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		872491 EPHA5_HUMAN (3-975): 0: 1117: 41.91		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		665661 EPHB2_HUMAN (27-975): 0: 1112: 41.01		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		171334 EPHB6_HUMAN (11-971): 0: 907: 36.44		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		600712 EPHA1_HUMAN (1-976): 0: 1103: 100.00		PKHA6_HUMAN (109-1116): 8.74e-73: 264: 28.52
+	Hs
		872669 EPHA4_HUMAN (5-975): 0: 1108: 43.50		MAGI2_HUMAN (4-650): 6.29e-50: 195: 11.18
+	Hs
		1072603 EPHA7_HUMAN (2-975): 0: 1117: 43.22		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		872492 EPHA5_HUMAN (3-975): 0: 1117: 41.91		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		665662 EPHB2_HUMAN (27-975): 0: 1112: 41.01		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		872712 EPHA4_HUMAN (5-975): 0: 1108: 43.50		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		665271 EPHA2_HUMAN (24-976): 0: 1056: 49.90		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Hs
		600632 EPHA1_HUMAN (1-976): 0: 1103: 100.00		TITIN_HUMAN (275-1090): 3.45e-10: 67: 9.15
+	Hs
		171335 EPHB6_HUMAN (11-971): 0: 907: 36.44		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		435765 IGF1R_HUMAN (269-885): 5.75e-137: 446: 21.38		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		674531 UFO_HUMAN (274-964): 2.03e-146: 459: 23.29		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		435768 IGF1R_HUMAN (269-885): 5.75e-137: 446: 21.38		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Rn
		94019 INSR_RAT (391-882): 7.67e-131: 430: 26.99		F1LLX6_RAT (70-775): 8.96e-41: 165: 11.16
+	Hs
		674522 UFO_HUMAN (274-964): 2.03e-146: 459: 23.29		WWP1_HUMAN (3-240): 7.83e-24: 110: 14.94
+	Hs
		983669 FAK1_HUMAN (630-884): 1.18e-63: 236: 45.88		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85