HitPredict - High confidence protein-protein interactions

Interactor 1: ZP3 (P21754)
Zona pellucida sperm-binding protein 3 (Sperm receptor) (ZP3A/ZP3B) (Zona pellucida glycoprotein 3) (Zp-3) (Zona pellucida protein C) [Cleaved into: Processed zona pellucida sperm-binding protein 3]
Gene: ZP3

Interactor 2: ZP3 (P21754)
Zona pellucida sperm-binding protein 3 (Sperm receptor) (ZP3A/ZP3B) (Zona pellucida glycoprotein 3) (Zp-3) (Zona pellucida protein C) [Cleaved into: Processed zona pellucida sperm-binding protein 3]
Gene: ZP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.804

Property	Details
Experiments	26879157, 28886344
Identification Methods	electron microscopy, x-ray crystallography, infrared spectroscopy, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	Zona_pellucida~Zona_pellucida
Common GO terms	GO:0001809 - positive regulation of type IV hypersensitivity GO:0001825 - blastocyst formation GO:0002455 - humoral immune response mediated by circulating immunoglobulin GO:0002687 - positive regulation of leukocyte migration GO:0002922 - positive regulation of humoral immune response and 25 others more... GO:0005201 - extracellular matrix structural constituent GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0007339 - binding of sperm to zona pellucida GO:0030246 - carbohydrate binding GO:0031012 - extracellular matrix GO:0032190 - acrosin binding GO:0032729 - positive regulation of type II interferon production GO:0032753 - positive regulation of interleukin-4 production GO:0035803 - egg coat formation GO:0035804 - structural constituent of egg coat GO:0035805 - egg coat GO:0042102 - positive regulation of T cell proliferation GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0048018 - receptor ligand activity GO:0048599 - oocyte development GO:0050729 - positive regulation of inflammatory response GO:0062023 - collagen-containing extracellular matrix GO:2000344 - positive regulation of acrosome reaction GO:2000360 - negative regulation of binding of sperm to zona pellucida GO:2000368 - positive regulation of acrosomal vesicle exocytosis GO:2000386 - positive regulation of ovarian follicle development GO:2000388 - positive regulation of antral ovarian follicle growth
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1	424
Hs

1	424

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Last updated: 15 Jul 2024