HitPredict

Interactor 1: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~fn3, Ig_3~fn3, EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0043235 - receptor complex GO:0070372 - regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 821 Hs			1 976
+	Hs
		601484 FGFR2_HUMAN (1-821): 0: 863: 100.00		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		507871 FGFR1_HUMAN (1-820): 0: 772: 71.17		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		507926 FGFR1_HUMAN (1-820): 0: 772: 71.17		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		609184 FGFR3_HUMAN (10-821): 0: 731: 65.69		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		609225 FGFR3_HUMAN (10-821): 0: 731: 65.69		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		607887 FGFR4_HUMAN (22-810): 0: 684: 55.86		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		607974 FGFR4_HUMAN (22-810): 0: 684: 55.86		EPHA7_HUMAN (4-974): 0: 1128: 50.30
+	Hs
		607929 FGFR4_HUMAN (22-810): 0: 684: 55.86		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		665142 EPHA3_HUMAN (18-778): 3.24e-168: 514: 18.30		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		665383 EPHA3_HUMAN (18-778): 3.24e-168: 514: 18.30		EPHA5_HUMAN (11-976): 0: 1127: 51.34
+	Hs
		665374 EPHA3_HUMAN (18-778): 3.24e-168: 514: 18.30		EPHB2_HUMAN (28-973): 0: 1089: 48.29
+	Hs
		665384 EPHA3_HUMAN (18-778): 3.24e-168: 514: 18.30		EPHB4_HUMAN (14-970): 0: 986: 44.99
+	Hs
		601456 FGFR2_HUMAN (1-821): 0: 863: 100.00		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		435514 FGFR1_HUMAN (1-820): 0: 772: 71.17		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		507857 FGFR1_HUMAN (1-820): 0: 772: 71.17		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		609173 FGFR3_HUMAN (10-821): 0: 731: 65.69		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		435536 FGFR4_HUMAN (22-810): 0: 684: 55.86		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		433573 FGFR2_HUMAN (1-821): 0: 863: 100.00		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433576 FGFR4_HUMAN (22-810): 0: 684: 55.86		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433602 EPHA3_HUMAN (18-778): 3.24e-168: 514: 18.30		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91