HitPredict

Interactor 1: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Interactor 2: KLOTB (Q86Z14)
Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)
Gene: KLB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17623664
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Glyco_hydro_1~I-set
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0017134 - fibroblast growth factor binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 821 Hs			1 1044
+	Hs
		508088 FGFR1_HUMAN (1-820): 0: 772: 71.17		KLOTB_HUMAN (1-1044): 0: 1400: 100.00
+	Hs
		609401 FGFR3_HUMAN (10-821): 0: 731: 65.69		KLOTB_HUMAN (1-1044): 0: 1400: 100.00
+	Mm
		555271 FGFR1_MOUSE (1-820): 0: 768: 70.57		KLOTB_MOUSE (1-1044): 0: 1356: 78.76
+	Hs
		608033 FGFR4_HUMAN (22-810): 0: 684: 55.86		KLOTB_HUMAN (1-1044): 0: 1400: 100.00
+	Mm
		192159 FGFR2_MOUSE (1-821): 0: 834: 96.96		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Mm
		192157 FGFR1_MOUSE (1-820): 0: 768: 70.57		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Mm
		975159 FGFR4_MOUSE (4-251): 6.36e-18: 90.6: 17.67		KLOTB_MOUSE (1-1044): 0: 1356: 78.76
+	Mm
		93854 E9QNJ9_MOUSE (4-249): 2.12e-19: 95.6: 14.96		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Mm
		192164 FGFR3_MOUSE (4-345): 1.13e-18: 93.3: 14.97		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Mm
		192163 FGFR4_MOUSE (4-251): 6.36e-18: 90.6: 17.67		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Ce
		1014307 EGL15_CAEEL (17-250): 1.43e-23: 109: 18.11		Q18758_CAEEL (521-963): 3.03e-156: 473: 24.44