HitPredict

Interactor 1: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Interactor 2: KDIS (Q9ULH0)
Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)
Gene: KIDINS220

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 33961781, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~I-set, Ank_2~I-set
Common GO terms	GO:0001701 - in utero embryonic development GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 821 Hs			1 1771
+	Hs
		608184 FGFR4_HUMAN (22-810): 0: 684: 55.86		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		665439 EPHA3_HUMAN (18-778): 3.24e-168: 514: 18.30		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		872504 EPHA5_HUMAN (18-766): 3.48e-163: 502: 17.53		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		674564 UFO_HUMAN (5-818): 3.59e-160: 490: 22.49		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		1081644 NTRK3_HUMAN (166-765): 7.85e-160: 488: 25.31		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		665360 EPHA2_HUMAN (18-798): 4.64e-157: 485: 19.21		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		1083907 NTRK2_HUMAN (123-765): 4.81e-153: 469: 23.43		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		385704 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Rn
		728451 NTRK1_RAT (161-772): 3.17e-146: 451: 25.08		KDIS_RAT (13-1771): 0: 2556: 93.24
+	Hs
		507831 FGFR1_HUMAN (1-820): 0: 772: 71.17		ANK1_HUMAN (96-531): 5.46e-92: 334: 20.00
+	Hs
		507971 FGFR1_HUMAN (1-820): 0: 772: 71.17		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		507954 FGFR1_HUMAN (1-820): 0: 772: 71.17		ANK2_HUMAN (3-233): 5.93e-53: 208: 25.11
+	Hs
		665591 EPHB2_HUMAN (9-766): 1.95e-166: 511: 17.58		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		1021409 NTRK3_HUMAN (166-765): 7.85e-160: 488: 25.31		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		665581 EPHB2_HUMAN (9-766): 1.95e-166: 511: 17.58		ANK2_HUMAN (3-233): 5.93e-53: 208: 25.11
+	Hs
		434183 RET_HUMAN (228-816): 2.74e-144: 455: 34.26		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		257545 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		ANR17_HUMAN (261-522): 2.37e-53: 209: 19.32
+	Hs
		384666 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		ANK2_HUMAN (3-233): 5.93e-53: 208: 25.11
+	Hs
		385170 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		ANR44_HUMAN (1-103): 1.28e-18: 94.8: 19.63
+	Hs
		166874 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		ANR28_HUMAN (411-503): 1.03e-09: 65.9: 6.45