HitPredict

Interactor 1: RYR1 (P21817)
Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
Gene: RYR1

Interactor 2: FKB1A (P62942)
Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)
Gene: FKBP1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	11171121, 12704193, 11279144, 18268335
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~RYDR_ITPR, FKBP_C~SPRY
Common GO terms	GO:0005737 - cytoplasm GO:0014802 - terminal cisterna GO:0016529 - sarcoplasmic reticulum GO:0030018 - Z disc GO:0033017 - sarcoplasmic reticulum membrane and 1 others more... GO:1990425 - ryanodine receptor complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 5038 Hs			1 108
+	Oc
		514745 RYR1_RABIT (1-5038): 0: 7952: 95.26		FKB1A_RABIT (1-108): 2e-54: 166: 100.00
+	Mm
		93348 RYR1_MOUSE (10-5038): 0: 7941: 94.99		FKB1A_MOUSE (1-108): 3.43e-54: 166: 97.22
+	Rn
		94032 RYR1_RAT (10-5037): 0: 7816: 92.34		FKB1A_RAT (1-108): 5.55e-54: 165: 97.22
+	Hs
		923834 RYR2_HUMAN (1-5038): 0: 7370: 64.76		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Mm
		93493 RYR2_MOUSE (1-5038): 0: 7378: 64.68		FKB1B_MOUSE (1-108): 3.25e-51: 158: 82.41
+	Hs
		932950 RYR2_HUMAN (1-5038): 0: 7370: 64.76		FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33
+	Hs
		923825 ITPR1_HUMAN (4781-5024): 3.83e-105: 382: 31.29		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		1012439 ASH2L_HUMAN (919-1226): 3.86e-56: 211: 18.44		Q0VDC6_HUMAN (1-108): 1.14e-53: 166: 100.00
+	Hs
		923827 RYR3_HUMAN (846-1049): 1.05e-21: 107: 31.28		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		932945 RYR3_HUMAN (846-1049): 1.05e-21: 107: 31.28		FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33