HitPredict

Interactor 1: RYR1 (P21817)
Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
Gene: RYR1

Interactor 2: HOME1 (Q86YM7)
Homer protein homolog 1 (Homer-1)
Gene: HOMER1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	12810060, 12223488
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0030018 - Z disc GO:0048741 - skeletal muscle fiber development
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 5038 Hs			1 354
+	Hs
		601674 RYR1_HUMAN (1-5038): 0: 8055: 100.00		HOME3_HUMAN (3-354): 3.77e-60: 199: 49.72
+	Hs
		601673 RYR1_HUMAN (1-5038): 0: 8055: 100.00		HOME2_HUMAN (1-351): 8.57e-56: 187: 51.00
+	Hs
		551607 RYR1_HUMAN (1-5038): 0: 8055: 100.00		DESP_HUMAN (95-342): 9.29e-09: 59.3: 12.30
+	Hs
		1205715 RYR2_HUMAN (1-5038): 0: 7370: 64.76		HOME1_HUMAN (1-354): 4.46e-62: 204: 100.00
+	Mm
		515786 ITPR1_MOUSE (4781-5024): 3.87e-105: 382: 30.95		HOME1_MOUSE (1-354): 2.36e-58: 194: 95.36
+	Hs
		1140529 RN123_HUMAN (1071-1225): 5.78e-43: 176: 26.42		MRCKG_HUMAN (183-349): 3.69e-10: 63.5: 17.24
+	Hs
		551740 RN123_HUMAN (1071-1225): 5.78e-43: 176: 26.42		DESP_HUMAN (95-342): 9.29e-09: 59.3: 12.30
+	Hs
		551717 RYR3_HUMAN (846-1049): 1.05e-21: 107: 31.28		DESP_HUMAN (95-342): 9.29e-09: 59.3: 12.30