HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: S10A4 (P26447)
Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)
Gene: S100A4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30083275
Identification Methods	cross-linking study, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1342 Hs			1 101
+	Hs
		601869 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		S10AA_HUMAN (1-100): 4.52e-32: 109: 34.00
+	Hs
		380734 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		S100B_HUMAN (3-91): 3.86e-31: 106: 47.19
+	Hs
		642945 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		S10A4_HUMAN (1-101): 9.21e-39: 126: 100.00
+	Hs
		685170 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		S10AB_HUMAN (2-97): 2.99e-36: 120: 27.84
+	Hs
		893799 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		S10AA_HUMAN (1-100): 4.52e-32: 109: 34.00
+	Hs
		383643 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		S10AB_HUMAN (2-97): 2.99e-36: 120: 27.84
+	Hs
		337962 EGFR_HUMAN (18-1157): 0: 1041: 42.30		S10A4_HUMAN (1-101): 9.21e-39: 126: 100.00
+	Hs
		338660 EGFR_HUMAN (18-1157): 0: 1041: 42.30		HORN_HUMAN (1-96): 6.3e-33: 121: 25.74
+	Hs
		338011 EGFR_HUMAN (18-1157): 0: 1041: 42.30		S10AB_HUMAN (2-97): 2.99e-36: 120: 27.84
+	Hs
		383930 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		S10AG_HUMAN (3-83): 1.43e-23: 87.9: 37.81
+	Hs
		338220 EGFR_HUMAN (18-1157): 0: 1041: 42.30		S10AA_HUMAN (1-100): 4.52e-32: 109: 34.00
+	Hs
		383989 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		S10AE_HUMAN (3-84): 7.11e-20: 78.7: 28.05
+	Hs
		337773 EGFR_HUMAN (18-1157): 0: 1041: 42.30		S10A9_HUMAN (3-91): 3.65e-28: 99.9: 31.11
+	Hs
		338001 EGFR_HUMAN (18-1157): 0: 1041: 42.30		S10A7_HUMAN (3-93): 4.96e-18: 74.1: 23.66
+	Hs
		416337 RET_HUMAN (518-1072): 1.47e-118: 399: 21.15		S10A9_HUMAN (3-91): 3.65e-28: 99.9: 31.11
+	Hs
		396674 INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51		S10A8_HUMAN (1-88): 8.31e-25: 91: 29.55