HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: CALX (P27824)
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Gene: CANX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	24189400, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1342 Hs			1 592
+	Hs
		161016 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		383628 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		337977 EGFR_HUMAN (18-1157): 0: 1041: 42.30		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		160994 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		337975 EGFR_HUMAN (18-1157): 0: 1041: 42.30		CALR_HUMAN (67-470): 1.19e-141: 418: 38.33
+	Hs
		434139 RET_HUMAN (518-1072): 1.47e-118: 399: 21.15		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		435545 IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		161053 ROR1_HUMAN (490-1147): 1.55e-126: 416: 17.37		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		161002 RET_HUMAN (518-1072): 1.47e-118: 399: 21.15		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		161003 IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		654090 EPHA3_HUMAN (691-978): 1.41e-41: 168: 34.13		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		411305 INSR_HUMAN (329-650): 2.27e-22: 106: 16.98		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		160999 INSR_HUMAN (329-650): 2.27e-22: 106: 16.98		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Rn
		544766 INSR_RAT (329-650): 1.42e-20: 101: 16.71		CALR_RAT (67-470): 7.8e-147: 431: 37.35