HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 18803287, 15812817, 12896906, 10383151, 24189400, 11694521, 11389077, 11546794, 22973453, 9756944, 9130710, 16273093, 20007781, 21278786, 22439932, 10572067, 20227043, 21075308
Identification Methods affinity chromatography technology, pull down, unspecified method, anti bait coimmunoprecipitation, protein array, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005886 - plasma membrane
GO:0043066 - negative regulation of apoptotic process
GO:0043125 - ErbB-3 class receptor binding
GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0046982 - protein heterodimerization activity
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024