HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	9019162, 24189400, 11546794, 16729043, 8665853, 22973453, 35384245, 9756944, 16273093, 24658140
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, unspecified method, protein array, tandem affinity purification, ubiquitin reconstruction
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007507 - heart development GO:0008284 - positive regulation of cell population proliferation GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 583
+	Hs
		601938 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53
+	Hs
		601962 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47
+	Hs
		601896 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88
+	Hs
		548637 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Hs
		601970 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		Q96D37_HUMAN (163-578): 1.11e-54: 200: 12.25
+	Hs
		601973 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SHD_HUMAN (328-582): 1.62e-47: 171: 23.02
+	Hs
		208992 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		601860 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97
+	Hs
		442779 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		561380 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FER_HUMAN (345-581): 6.27e-42: 163: 18.75
+	Hs
		601926 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		601949 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55
+	Hs
		557604 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		275537 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		BCAR3_HUMAN (379-583): 3.82e-38: 152: 23.83
+	Hs
		601815 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		426945 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FES_HUMAN (326-581): 1.46e-37: 150: 21.79
+	Hs
		601921 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		GRB7_HUMAN (371-563): 3.91e-33: 135: 21.57
+	Hs
		601964 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		P55G_HUMAN (473-581): 3.75e-31: 128: 29.20
+	Hs
		129200 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		601876 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48