HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 635
+	Hs
		601842 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ZAP70_HUMAN (6-635): 0: 535: 53.57
+	Hs
		507855 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		601907 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ITK_HUMAN (136-626): 3.44e-108: 341: 27.60
+	Hs
		411594 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LCK_HUMAN (5-201): 3.03e-71: 240: 23.29
+	Hs
		522774 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		433253 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		YES_HUMAN (4-203): 1.25e-68: 234: 20.80
+	Hs
		442779 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		HCK_HUMAN (4-371): 1.18e-67: 231: 14.65
+	Hs
		337346 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL1_HUMAN (4-385): 1.81e-58: 214: 17.07
+	Hs
		601925 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ERBB4_HUMAN (375-619): 7.14e-57: 210: 43.15
+	Hs
		337928 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		601837 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL2_HUMAN (4-193): 3.72e-56: 207: 19.54
+	Hs
		383606 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34
+	Hs
		601920 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FAK2_HUMAN (374-630): 9.56e-53: 197: 40.15
+	Hs
		601835 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TEC_HUMAN (4-379): 4.35e-48: 180: 12.71
+	Mm
		936771 ERBB3_MOUSE (1-1341): 0: 1363: 90.53		ERBB2_MOUSE (375-619): 4.16e-52: 196: 42.34
+	Hs
		601856 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		BLK_HUMAN (162-267): 2.8e-29: 123: 32.43
+	Hs
		601836 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TXK_HUMAN (15-201): 5.99e-17: 86.1: 22.90
+	Hs
		601919 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PTK6_HUMAN (14-200): 1.27e-14: 78.4: 20.87
+	Rn
		1144089 ERBB4_RAT (1-1330): 0: 1159: 45.68		ERBB4_RAT (375-619): 7.21e-57: 210: 43.15
+	Mm
		1142640 ERBB4_MOUSE (1-1330): 0: 1167: 45.98		FAK2_MOUSE (374-630): 1.35e-53: 199: 40.15