HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 304
+	Hs
		601845 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		548637 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		601970 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		Q96D37_HUMAN (11-189): 5.17e-47: 170: 28.21
+	Hs
		602023 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV3_HUMAN (11-189): 1.56e-33: 131: 26.15
+	Hs
		275172 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17
+	Hs
		601860 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		580925 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		562623 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		601876 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		208992 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557604 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		802607 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		802847 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		548711 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		275197 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17
+	Hs
		855797 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		581010 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		562648 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		209056 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557701 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00