HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 303
+	Hs
		601844 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		601860 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV2_HUMAN (14-180): 4.46e-40: 150: 19.80
+	Hs
		275172 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97
+	Hs
		580925 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		562623 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10
+	Hs
		557604 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81
+	Hs
		601970 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		Q96D37_HUMAN (214-293): 2.34e-15: 78.3: 30.86
+	Hs
		548637 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV_HUMAN (214-293): 3.43e-15: 77.9: 30.86
+	Hs
		602023 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV3_HUMAN (169-293): 7.06e-15: 76.8: 26.98
+	Hs
		601830 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		CSK_HUMAN (129-180): 8.43e-11: 64.1: 43.40
+	Hs
		601876 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		208992 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NCK2_HUMAN (72-204): 1.51e-09: 60.1: 21.48
+	Hs
		802847 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00
+	Hs
		802607 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		275197 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97
+	Hs
		581010 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		562648 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10
+	Hs
		557701 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81
+	Hs
		548711 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		VAV_HUMAN (214-293): 3.43e-15: 77.9: 30.86
+	Hs
		209056 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		NCK2_HUMAN (72-204): 1.51e-09: 60.1: 21.48