HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	27793840, 24662824
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 1319
+	Hs
		808132 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		338105 EGFR_HUMAN (18-1157): 0: 1041: 42.30		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		337392 ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		434157 RET_HUMAN (518-1072): 1.47e-118: 399: 21.15		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		601981 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		435577 IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		338861 EGFR_HUMAN (18-1157): 0: 1041: 42.30		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		338634 EGFR_HUMAN (18-1157): 0: 1041: 42.30		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		601974 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Hs
		337535 ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		1071010 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		1070998 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Hs
		338959 EGFR_HUMAN (18-1157): 0: 1041: 42.30		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		383984 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86
+	Hs
		338840 EGFR_HUMAN (18-1157): 0: 1041: 42.30		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Hs
		338999 EGFR_HUMAN (18-1157): 0: 1041: 42.30		SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86
+	Hs
		339005 EGFR_HUMAN (18-1157): 0: 1041: 42.30		SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82
+	Hs
		339072 EGFR_HUMAN (18-1157): 0: 1041: 42.30		HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83
+	Hs
		337496 ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Mm
		222826 ACK1_MOUSE (677-1328): 5.23e-124: 413: 21.75		NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29