HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 1124
+	Hs
		238355 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		JAK2_HUMAN (7-1101): 0: 889: 47.80
+	Hs
		601837 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL2_HUMAN (794-1121): 3.94e-95: 331: 32.22
+	Hs
		337346 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48
+	Hs
		522774 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25
+	Hs
		433253 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		YES_HUMAN (784-1109): 7.17e-99: 326: 29.36
+	Hs
		411594 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50
+	Hs
		442779 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		HCK_HUMAN (794-1110): 1.01e-94: 314: 28.93
+	Hs
		454797 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FGR_HUMAN (783-1110): 2.27e-93: 310: 28.88
+	Hs
		601925 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ERBB4_HUMAN (822-1104): 2.36e-87: 310: 36.62
+	Hs
		433575 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LYN_HUMAN (781-1110): 2.14e-92: 307: 28.40
+	Hs
		601856 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		BLK_HUMAN (784-1105): 3.14e-89: 298: 29.63
+	Hs
		337480 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48
+	Hs
		337928 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34
+	Hs
		601843 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		KSYK_HUMAN (525-773): 5e-18: 91.3: 27.13
+	Hs
		601842 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ZAP70_HUMAN (527-773): 4.08e-17: 88.6: 28.02
+	Hs
		601830 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		CSK_HUMAN (521-787): 4.41e-17: 87.4: 27.01
+	Rn
		1144089 ERBB4_RAT (1-1330): 0: 1159: 45.68		ERBB4_RAT (773-1098): 6.91e-88: 312: 35.17
+	Hs
		383606 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ERBB2_HUMAN (527-780): 1.84e-13: 77.4: 25.00
+	Mm
		936771 ERBB3_MOUSE (1-1341): 0: 1363: 90.53		ERBB2_MOUSE (527-780): 4.97e-13: 75.9: 24.62
+	Hs
		338460 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34