HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.890

Property	Details
Experiments	24189400, 16729043, 9756944, 24658140
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, ubiquitin reconstruction
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0014044 - Schwann cell development GO:0042552 - myelination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 217
+	Hs
		602023 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00
+	Hs
		411594 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		601830 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		601919 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		557604 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337346 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		601837 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		548637 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		601970 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		Q96D37_HUMAN (2-60): 8.82e-15: 74.6: 42.37
+	Hs
		433253 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		454797 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FGR_HUMAN (120-215): 6.83e-13: 68.8: 22.45
+	Hs
		442779 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		433575 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522774 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		601860 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Hs
		275172 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62
+	Hs
		411729 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		337480 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		412202 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		275197 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62