HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: ACTS (P68133)
Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]
Gene: ACTA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24189400
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005615 - extracellular space GO:0010628 - positive regulation of gene expression
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1342 Hs			1 377
+	Hs
		601868 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		601878 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Hs
		601880 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ACTC_HUMAN (1-377): 0: 604: 98.94
+	Hs
		601872 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ACTA_HUMAN (1-377): 0: 602: 97.88
+	Hs
		601879 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ACTH_HUMAN (4-377): 0: 597: 98.40
+	Hs
		383719 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		338264 EGFR_HUMAN (18-1157): 0: 1041: 42.30		ACTS_HUMAN (1-377): 0: 605: 100.00
+	Hs
		338216 EGFR_HUMAN (18-1157): 0: 1041: 42.30		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		338243 EGFR_HUMAN (18-1157): 0: 1041: 42.30		ACTA_HUMAN (1-377): 0: 602: 97.88
+	Hs
		337422 ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51		ACTS_HUMAN (1-377): 0: 605: 100.00
+	Hs
		411346 INSR_HUMAN (329-650): 2.27e-22: 106: 16.98		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Rn
		544802 INSR_RAT (329-650): 1.42e-20: 101: 16.71		ACTB_RAT (5-377): 0: 604: 93.83