HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: NRG1 (Q02297)
Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]
Gene: NRG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 11389077, 10913256, 30523157, 11555649, 7592681, 9168115, 33961781, 17697999, unassigned1913, 28988771
Identification Methods pull down, affinity chromatography technology, x ray scattering, split luciferase complementation, comigration in non denaturing gel electrophoresis, cosedimentation in solution, light scattering, surface plasmon resonance, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains EGF~Furin-like, EGF~Recep_L_domain
Common GO terms GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0008284 - positive regulation of cell population proliferation
GO:0016324 - apical plasma membrane
and 5 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

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Hs

1 640
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Last updated: 15 Jul 2024