HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: GRB7 (Q14451)
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Gene: GRB7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	9516479, 24189400, 22973453, 16273093
Identification Methods	affinity chromatography technology, pull down, unspecified method, protein array, competition binding, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 532
+	Hs
		601970 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		Q96D37_HUMAN (84-526): 8.36e-87: 286: 15.27
+	Hs
		548637 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV_HUMAN (84-526): 4.42e-86: 285: 15.27
+	Hs
		601860 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV2_HUMAN (81-526): 4.93e-78: 264: 14.77
+	Hs
		602023 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV3_HUMAN (81-526): 1.65e-62: 221: 10.44
+	Hs
		411594 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LCK_HUMAN (317-527): 2.74e-57: 200: 20.00
+	Hs
		601907 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ITK_HUMAN (232-527): 1.19e-54: 196: 18.10
+	Hs
		580925 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Hs
		601902 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		BTK_HUMAN (192-529): 1.31e-48: 180: 13.86
+	Hs
		433575 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LYN_HUMAN (347-531): 4.7e-49: 178: 18.46
+	Hs
		454797 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FGR_HUMAN (345-527): 5.44e-48: 176: 21.65
+	Hs
		433253 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		YES_HUMAN (366-528): 8.94e-48: 175: 19.53
+	Hs
		522774 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Hs
		442779 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		HCK_HUMAN (349-527): 4.62e-45: 168: 19.37
+	Hs
		601998 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SLAP2_HUMAN (355-528): 3.54e-42: 153: 19.55
+	Hs
		601834 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		MATK_HUMAN (398-525): 4.78e-36: 142: 30.37
+	Hs
		601830 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		CSK_HUMAN (394-525): 1.94e-28: 119: 28.78
+	Hs
		601843 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		KSYK_HUMAN (412-531): 6.62e-17: 86: 30.00
+	Hs
		601876 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Hs
		411729 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		LCK_HUMAN (317-527): 2.74e-57: 200: 20.00
+	Hs
		412202 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		FYN_HUMAN (357-529): 5.57e-50: 182: 20.88