HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	24189400, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1342 Hs			1 378
+	Hs
		383832 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		338485 EGFR_HUMAN (18-1157): 0: 1041: 42.30		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		968308 ROR1_HUMAN (490-1147): 1.55e-126: 416: 17.37		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		434207 RET_HUMAN (518-1072): 1.47e-118: 399: 21.15		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		435654 IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665610 EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665253 EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		872655 EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		992579 ACK1_HUMAN (683-961): 1.22e-46: 184: 38.73		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		789071 ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665401 EPHA3_HUMAN (691-978): 1.41e-41: 168: 34.13		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		983619 FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1079717 Q15850_HUMAN (713-976): 1.8e-42: 163: 30.35		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		411399 INSR_HUMAN (329-650): 2.27e-22: 106: 16.98		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		537743 INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Dm
		448241 INSR_DROME (350-641): 4.37e-33: 142: 17.97		CDC37_DROME (1-351): 1.28e-126: 371: 52.54