HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: BLNK (Q8WV28)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Gene: BLNK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0010628 - positive regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 456
+	Hs
		129200 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		601815 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		601909 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27
+	Hs
		601964 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		P55G_HUMAN (327-453): 3.31e-27: 115: 24.41
+	Hs
		601935 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS3_HUMAN (10-436): 9.07e-25: 109: 15.25
+	Hs
		601934 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS2_HUMAN (45-436): 3.69e-23: 105: 18.06
+	Hs
		602002 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS1_HUMAN (18-436): 4.14e-23: 105: 14.61
+	Hs
		601945 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS4_HUMAN (81-436): 3.69e-20: 95.6: 13.70
+	Hs
		129295 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		655377 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		1024132 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27
+	Hs
		1070991 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		P55G_HUMAN (327-453): 3.31e-27: 115: 24.41
+	Hs
		1070975 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS3_HUMAN (10-436): 9.07e-25: 109: 15.25
+	Hs
		1070974 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS2_HUMAN (45-436): 3.69e-23: 105: 18.06
+	Hs
		1071015 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS1_HUMAN (18-436): 4.14e-23: 105: 14.61
+	Hs
		1070981 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS4_HUMAN (81-436): 3.69e-20: 95.6: 13.70
+	Mm
		643074 ERBB2_MOUSE (10-1222): 0: 1080: 39.36		P85A_MOUSE (121-453): 4.26e-43: 163: 14.41
+	Hs
		129159 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		383629 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		383773 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27