HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: ACTBM (Q9BYX7)
Putative beta-actin-like protein 3 (Kappa-actin) (POTE ankyrin domain family member K)
Gene: POTEKP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	24189400
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1342 Hs			1 375
+	Hs
		60297 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		POTEF_HUMAN (1-375): 0: 746: 94.13
+	Hs
		601939 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		POTEE_HUMAN (1-375): 0: 637: 95.20
+	Hs
		601868 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ACTB_HUMAN (1-375): 0: 599: 91.47
+	Hs
		601878 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ACTG_HUMAN (1-375): 0: 599: 90.93
+	Hs
		601872 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ACTA_HUMAN (2-375): 0: 589: 86.90
+	Hs
		601880 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ACTC_HUMAN (2-375): 0: 589: 87.17
+	Hs
		601881 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ACTS_HUMAN (2-375): 0: 589: 86.63
+	Hs
		601879 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ACTH_HUMAN (2-375): 0: 587: 86.63
+	Hs
		383719 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		ACTB_HUMAN (1-375): 0: 599: 91.47
+	Hs
		338216 EGFR_HUMAN (18-1157): 0: 1041: 42.30		ACTB_HUMAN (1-375): 0: 599: 91.47
+	Hs
		338243 EGFR_HUMAN (18-1157): 0: 1041: 42.30		ACTA_HUMAN (2-375): 0: 589: 86.90
+	Hs
		338264 EGFR_HUMAN (18-1157): 0: 1041: 42.30		ACTS_HUMAN (2-375): 0: 589: 86.63
+	Hs
		337422 ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51		ACTS_HUMAN (2-375): 0: 589: 86.63
+	Hs
		411283 INSR_HUMAN (329-650): 2.27e-22: 106: 16.98		POTEJ_HUMAN (1-375): 0: 747: 94.40
+	Hs
		411346 INSR_HUMAN (329-650): 2.27e-22: 106: 16.98		ACTB_HUMAN (1-375): 0: 599: 91.47
+	Rn
		544802 INSR_RAT (329-650): 1.42e-20: 101: 16.71		ACTB_RAT (1-375): 0: 599: 91.47