HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 847
+	Hs
		548637 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		601860 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		VAV2_HUMAN (1-846): 0: 574: 50.00
+	Hs
		601970 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		Q96D37_HUMAN (69-846): 0: 546: 55.77
+	Hs
		1071026 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		VAV3_HUMAN (1-847): 0: 663: 100.00
+	Hs
		548711 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		855797 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		VAV2_HUMAN (1-846): 0: 574: 50.00
+	Hs
		383580 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		VAV_HUMAN (1-846): 0: 609: 57.31
+	Mm
		654977 EGFR_MOUSE (20-1145): 0: 1071: 43.44		VAV_MOUSE (1-846): 0: 600: 57.90
+	Hs
		562623 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		580925 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		601876 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		224717 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		KALRN_HUMAN (152-705): 9.15e-54: 205: 14.14
+	Mm
		964564 EGFR_MOUSE (20-1145): 0: 1071: 43.44		FGD5_MOUSE (1-601): 4e-77: 274: 11.65
+	Hs
		562648 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		581010 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		924589 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Mm
		964571 EGFR_MOUSE (20-1145): 0: 1071: 43.44		ARHG7_MOUSE (747-847): 1.35e-14: 80.2: 27.72
+	Hs
		383591 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		383601 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Mm
		964559 EGFR_MOUSE (20-1145): 0: 1071: 43.44		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39