HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: DAPP1 (Q9UN19)
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa)
Gene: DAPP1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 280
+	Hs
		433253 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		YES_HUMAN (4-280): 3.38e-57: 193: 19.11
+	Hs
		522774 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SRC_HUMAN (4-280): 1.79e-56: 191: 18.09
+	Hs
		454797 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FGR_HUMAN (4-280): 1.36e-55: 189: 17.41
+	Hs
		433575 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LYN_HUMAN (3-280): 2.64e-55: 187: 18.37
+	Hs
		337346 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL1_HUMAN (8-280): 6.5e-51: 181: 17.61
+	Hs
		411594 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LCK_HUMAN (3-280): 6.43e-53: 181: 20.07
+	Hs
		601837 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL2_HUMAN (8-280): 1.94e-50: 180: 17.25
+	Hs
		442779 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		HCK_HUMAN (3-280): 2.17e-51: 177: 20.07
+	Hs
		561380 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FER_HUMAN (9-280): 1.14e-46: 168: 16.85
+	Hs
		601856 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		BLK_HUMAN (4-280): 6.05e-48: 168: 17.47
+	Hs
		601836 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TXK_HUMAN (9-280): 1.41e-44: 159: 14.29
+	Hs
		601902 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		BTK_HUMAN (3-280): 2.37e-43: 158: 14.68
+	Hs
		601830 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		CSK_HUMAN (10-280): 6.53e-43: 153: 13.07
+	Hs
		208992 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NCK2_HUMAN (6-129): 4.71e-41: 147: 28.00
+	Hs
		557604 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NCK1_HUMAN (34-127): 1.07e-39: 143: 34.04
+	Hs
		601901 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PTN11_HUMAN (35-225): 1.69e-29: 118: 22.28
+	Hs
		596357 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		RASA1_HUMAN (17-137): 2.1e-23: 101: 25.81
+	Hs
		580925 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PLCG1_HUMAN (4-184): 1.67e-22: 99.1: 23.00
+	Hs
		601817 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PTN6_HUMAN (35-184): 4.37e-22: 97.5: 25.31
+	Hs
		562623 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PLCG2_HUMAN (8-198): 3.87e-21: 94.8: 20.28