HitPredict

Interactor 1: POTEF (A5A3E0)
POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein)
Gene: POTEF

Interactor 2: GELS (P06396)
Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)
Gene: GSN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Gelsolin
Common GO terms	GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0070062 - extracellular exosome GO:0072562 - blood microparticle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1075 Hs			1 782
+	Hs
		413807 POTEI_HUMAN (1-1075): 0: 1112: 96.74		GELS_HUMAN (1-782): 0: 1207: 100.00
+	Hs
		474864 POTEI_HUMAN (1-1075): 0: 1112: 96.74		SCIN_HUMAN (51-768): 0: 1007: 59.72
+	Hs
		60455 POTEF_HUMAN (1-1075): 0: 1112: 100.00		SCIN_HUMAN (51-768): 0: 1007: 59.72
+	Hs
		413874 ACTB_HUMAN (701-1075): 0: 584: 91.47		GELS_HUMAN (1-782): 0: 1207: 100.00
+	Hs
		413884 ACTG_HUMAN (701-1075): 0: 584: 90.93		GELS_HUMAN (1-782): 0: 1207: 100.00
+	Hs
		413885 ACTC_HUMAN (701-1075): 0: 579: 86.67		GELS_HUMAN (1-782): 0: 1207: 100.00
+	Hs
		413881 ACTA_HUMAN (703-1075): 0: 578: 86.86		GELS_HUMAN (1-782): 0: 1207: 100.00
+	Hs
		413886 ACTS_HUMAN (701-1075): 0: 578: 86.13		GELS_HUMAN (1-782): 0: 1207: 100.00
+	Oc
		101997 ACTB_RABIT (701-1075): 0: 582: 91.20		G1U9R8_RABIT (44-782): 0: 1156: 94.59
+	Hs
		892149 ACTB_HUMAN (701-1075): 0: 584: 91.47		SCIN_HUMAN (51-768): 0: 1007: 59.72
+	Hs
		930076 ACTG_HUMAN (701-1075): 0: 584: 90.93		SCIN_HUMAN (51-768): 0: 1007: 59.72
+	Hs
		932481 ACTC_HUMAN (701-1075): 0: 579: 86.67		SCIN_HUMAN (51-768): 0: 1007: 59.72
+	Hs
		915546 ACTA_HUMAN (703-1075): 0: 578: 86.86		SCIN_HUMAN (51-768): 0: 1007: 59.72
+	Hs
		933081 ACTS_HUMAN (701-1075): 0: 578: 86.13		SCIN_HUMAN (51-768): 0: 1007: 59.72
+	Dm
		501491 ACT1_DROME (702-1075): 0: 582: 89.84		QUAI_DROME (41-781): 0: 639: 23.78
+	Hs
		891735 ACTB_HUMAN (701-1075): 0: 584: 91.47		FLII_HUMAN (373-765): 2.36e-57: 214: 22.88
+	Hs
		929839 ACTG_HUMAN (701-1075): 0: 584: 90.93		FLII_HUMAN (373-765): 2.36e-57: 214: 22.88
+	Hs
		932132 ACTC_HUMAN (701-1075): 0: 579: 86.67		FLII_HUMAN (373-765): 2.36e-57: 214: 22.88
+	Bt
		221227 ACTB_BOVIN (701-1075): 0: 584: 91.47		SVIL_BOVIN (565-781): 9.32e-25: 113: 23.26
+	Hs
		313786 ACTB_HUMAN (701-1075): 0: 584: 91.47		SVIL_HUMAN (551-779): 2.11e-24: 112: 21.86