HitPredict

Interactor 1: OSBP1 (P22059)
Oxysterol-binding protein 1
Gene: OSBP

Interactor 2: PKHA3 (Q9HB20)
Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1)
Gene: PLEKHA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PH
Common GO terms	GO:0000139 - Golgi membrane GO:0005794 - Golgi apparatus GO:0005802 - trans-Golgi network GO:0005829 - cytosol GO:0070273 - phosphatidylinositol-4-phosphate binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 807 Hs			1 300
+	Hs
		603083 OSBP1_HUMAN (1-807): 0: 750: 100.00		PKHA8_HUMAN (1-300): 1.05e-60: 202: 46.05
+	Hs
		603080 OSBP1_HUMAN (1-807): 0: 750: 100.00		OSBP2_HUMAN (2-231): 7.71e-45: 164: 23.74
+	Hs
		1302530 OSB11_HUMAN (93-793): 5.38e-157: 477: 18.24		OSBL9_HUMAN (1-294): 4e-43: 159: 21.54
+	Hs
		1302525 OSBL9_HUMAN (87-766): 3.83e-152: 464: 20.53		OSBL9_HUMAN (1-294): 4e-43: 159: 21.54
+	Hs
		1315180 OSB11_HUMAN (93-793): 5.38e-157: 477: 18.24		OSB10_HUMAN (1-298): 7.33e-34: 132: 16.14
+	Hs
		1302531 OSBL9_HUMAN (87-766): 3.83e-152: 464: 20.53		OSB10_HUMAN (1-298): 7.33e-34: 132: 16.14
+	Dm
		90649 E1JH23_DROME (317-705): 6.66e-104: 327: 18.89		Q9Y128_DROME (1-295): 4.16e-44: 160: 19.29
+	Dm
		90647 E1JH23_DROME (317-705): 6.66e-104: 327: 18.89		Q9W0K9_DROME (3-189): 1.66e-37: 134: 18.72
+	Dm
		1376142 Q9Y128_DROME (71-390): 3.03e-59: 213: 23.12		Q9W0K9_DROME (3-189): 1.66e-37: 134: 18.72
+	Hs
		1335073 PKHA3_HUMAN (92-288): 8.47e-20: 92.8: 31.84		PKHA3_HUMAN (1-300): 5.99e-78: 241: 100.00
+	Hs
		1294962 PKHA3_HUMAN (92-288): 8.47e-20: 92.8: 31.84		PKHA8_HUMAN (1-300): 1.05e-60: 202: 46.05
+	Sc
		728866 OSH1_YEAST (87-518): 1.99e-20: 99.2: 14.38		OSH1_YEAST (2-221): 1.72e-41: 155: 23.48
+	Sc
		728884 OSH1_YEAST (87-518): 1.99e-20: 99.2: 14.38		OSH2_YEAST (2-278): 3.54e-38: 145: 20.70
+	Sc
		1015616 OSH2_YEAST (83-417): 9.27e-20: 96.9: 17.54		OSH2_YEAST (2-278): 3.54e-38: 145: 20.70
+	Hs
		313162 PKHA8_HUMAN (92-231): 3.9e-17: 87.4: 37.32		PKHA9_HUMAN (117-213): 1.82e-21: 95.3: 42.27