HitPredict

Interactor 1: CLH (P22137)
Clathrin heavy chain
Gene: CHC1

Interactor 2: END3 (P39013)
Actin cytoskeleton-regulatory complex protein END3 (Endocytosis protein 3)
Gene: END3

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	32400111, 37968396
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006897 - endocytosis GO:0030479 - actin cortical patch
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1653 Sc			1 349
+	Hs
		787895 CLH1_HUMAN (4-1648): 0: 2909: 49.76		EPS15_HUMAN (10-348): 7.95e-34: 134: 15.69
+	Hs
		960975 CLH1_HUMAN (4-1648): 0: 2909: 49.76		EHD1_HUMAN (89-222): 8.21e-26: 110: 17.52
+	Dm
		112571 CLH_DROME (4-1650): 0: 2804: 48.58		M9ND00_DROME (3-349): 2.41e-60: 211: 15.58
+	Hs
		960966 CLH1_HUMAN (4-1648): 0: 2909: 49.76		EHD4_HUMAN (112-228): 1.61e-13: 73.4: 18.80
+	Hs
		960815 CLH1_HUMAN (4-1648): 0: 2909: 49.76		ITSN1_HUMAN (124-241): 2.14e-09: 61.1: 12.30
+	Dm
		669597 CLH_DROME (4-1650): 0: 2804: 48.58		Q8T8W3_DROME (130-221): 4.84e-12: 68.8: 21.74
+	Ce
		712340 CLH_CAEEL (4-1650): 0: 2715: 46.52		Q9U2T9_CAEEL (3-349): 2.24e-16: 82.3: 11.75
+	Sc
		604369 CLH_YEAST (1-1653): 0: 2506: 100.00		PAN1_YEAST (4-82): 2.84e-14: 76.1: 27.50