HitPredict

Interactor 1: RPA2 (P22138)
DNA-directed RNA polymerase I subunit RPA135 (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (A135) (DNA-directed RNA polymerase I polypeptide 2) (RNA polymerase I subunit 2)
Gene: RPA135

Interactor 2: RPA2 (P22138)
DNA-directed RNA polymerase I subunit RPA135 (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (A135) (DNA-directed RNA polymerase I polypeptide 2) (RNA polymerase I subunit 2)
Gene: RPA135

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

The method score is based on:

Property	Details
Experiments	22940862, 23209026
Identification Methods	affinity chromatography technology
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	RNA_pol_Rpa2_4~RNA_pol_Rpb2_1, RNA_pol_Rpa2_4~RNA_pol_Rpb2_3, RNA_pol_Rpb2_1~RNA_pol_Rpb2_1, RNA_pol_Rpb2_1~RNA_pol_Rpb2_3, RNA_pol_Rpb2_1~RNA_pol_Rpb2_6, RNA_pol_Rpb2_3~RNA_pol_Rpb2_6, RNA_pol_Rpb2_6~RNA_pol_Rpb2_6, RNA_pol_Rpb2_6~RNA_pol_Rpb2_7
Common GO terms	GO:0001054 - RNA polymerase I activity GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005736 - RNA polymerase I complex GO:0006360 - transcription by RNA polymerase I and 7 others more... GO:0006361 - transcription initiation at RNA polymerase I promoter GO:0006362 - transcription elongation by RNA polymerase I GO:0006363 - termination of RNA polymerase I transcription GO:0032549 - ribonucleoside binding GO:0042254 - ribosome biogenesis GO:0042790 - nucleolar large rRNA transcription by RNA polymerase I GO:0046872 - metal ion binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1	1203
Sc

1	1203

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Last updated: 15 Jul 2024