HitPredict

Interactor 1: RPA2 (P22138)
DNA-directed RNA polymerase I subunit RPA135 (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (A135) (DNA-directed RNA polymerase I polypeptide 2) (RNA polymerase I subunit 2)
Gene: RPA135

Interactor 2: RPA43 (P46669)
DNA-directed RNA polymerase I subunit RPA43 (A43) (DNA-directed DNA-dependent RNA polymerase 36 kDa polypeptide)
Gene: RPA43

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

The method score is based on:

Property	Details
Experiments	15477604, 22940862, 23209026, 10791972, 16554755, 16429126, 18160037, 37968396, 24153184
Identification Methods	affinity chromatography technology, biochemical, x-ray crystallography, tandem affinity purification
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	RNA_pol_Rpb2_1~RPA43_OB, RNA_pol_Rpb2_7~RPA43_OB, RNA_pol_Rpb2_7~SHS2_Rpb7-N
Common GO terms	GO:0001054 - RNA polymerase I activity GO:0005634 - nucleus GO:0005736 - RNA polymerase I complex GO:0006360 - transcription by RNA polymerase I GO:0006361 - transcription initiation at RNA polymerase I promoter and 4 others more... GO:0006362 - transcription elongation by RNA polymerase I GO:0006363 - termination of RNA polymerase I transcription GO:0042254 - ribosome biogenesis GO:0042790 - nucleolar large rRNA transcription by RNA polymerase I
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	1203
Sc

1	326

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024