HitPredict

Interactor 1: PSB4 (P22141)
Proteasome subunit beta type-4 (Macropain subunit C11) (Multicatalytic endopeptidase complex subunit C11) (Proteasome component C11) (Proteinase YSCE subunit 11)
Gene: PRE1

Interactor 2: PSA2 (P23639)
Proteasome subunit alpha type-2 (Macropain subunit Y7) (Multicatalytic endopeptidase complex subunit Y7) (Proteasome component Y7) (Proteinase YSCE subunit 7)
Gene: PRE8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.982

Property	Details
Experiments	11805837, 15242647, 16554755, 28322792, 12409293, 18435761, 37653242, 15917626, 21321079, 21878652, 22940862, 32868373, 37968396, 14759368, 17431397
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, biochemical, pull down, tandem affinity purification
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0010499 - proteasomal ubiquitin-independent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Sc			1 250
+	Dm
		771317 Q9VJJ0_DROME (1-197): 4.53e-85: 251: 40.10		PSA2_DROME (2-250): 2.44e-105: 306: 53.41
+	Dm
		771323 PSB2_DROME (1-196): 1.25e-77: 232: 32.65		PSA2_DROME (2-250): 2.44e-105: 306: 53.41
+	Dm
		1278644 Q9VJJ0_DROME (1-197): 4.53e-85: 251: 40.10		PSA5_DROME (3-250): 5e-93: 275: 30.59
+	Dm
		771294 Q7K148_DROME (2-197): 2.75e-66: 206: 20.92		PSA2_DROME (2-250): 2.44e-105: 306: 53.41
+	Sp
		999713 PSB4_SCHPO (1-193): 1.2e-80: 239: 53.89		PSA3_SCHPO (1-220): 2.47e-91: 271: 33.33
+	Dm
		1278649 PSB2_DROME (1-196): 1.25e-77: 232: 32.65		PSA5_DROME (3-250): 5e-93: 275: 30.59
+	Hs
		656174 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSA5_HUMAN (3-250): 9.42e-92: 272: 30.04
+	Hs
		638086 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSA4_HUMAN (1-247): 4.63e-91: 270: 34.40
+	Hs
		832080 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54
+	Hs
		832138 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSMA8_HUMAN (1-232): 2.48e-90: 268: 35.42
+	Hs
		156252 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSA7_HUMAN (1-248): 8.69e-90: 267: 32.00
+	Hs
		637649 PSB2_HUMAN (1-196): 1.09e-76: 230: 44.39		PSA2_HUMAN (1-250): 3.12e-90: 267: 56.97
+	Dm
		1178944 Q7K148_DROME (2-197): 2.75e-66: 206: 20.92		PSA5_DROME (3-250): 5e-93: 275: 30.59
+	Hs
		638065 PSB8_HUMAN (2-197): 5.21e-68: 210: 22.45		PSA4_HUMAN (1-247): 4.63e-91: 270: 34.40
+	Hs
		656051 PSB8_HUMAN (2-197): 5.21e-68: 210: 22.45		PSA6_HUMAN (2-250): 4.86e-91: 270: 32.54
+	Hs
		156228 PSB8_HUMAN (2-197): 5.21e-68: 210: 22.45		PSA7_HUMAN (1-248): 8.69e-90: 267: 32.00
+	Hs
		637629 PSB8_HUMAN (2-197): 5.21e-68: 210: 22.45		PSA2_HUMAN (1-250): 3.12e-90: 267: 56.97
+	Hs
		156233 PSB5_HUMAN (2-197): 5.07e-66: 205: 20.92		PSA7_HUMAN (1-248): 8.69e-90: 267: 32.00
+	Sp
		999845 PSB4_SCHPO (1-193): 1.2e-80: 239: 53.89		PSA4_SCHPO (5-214): 2.08e-41: 144: 38.39
+	Sp
		195132 PSB1_SCHPO (3-191): 3.4e-67: 207: 23.28		PSA4_SCHPO (5-214): 2.08e-41: 144: 38.39