HitPredict

Interactor 1: A5D6Q2 (A5D6Q2)
Ncoa3 protein
Gene: Ncoa3

Interactor 2: RORB (Q8R1B8)
Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)
Gene: RORB

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	20211142
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1353 Mm			1 470
+	Mm
		985522 Q05BA5_MOUSE (1-1353): 1.49e-167: 540: 100.00		RORB_MOUSE (1-470): 1.72e-142: 418: 100.00
+	Mm
		222608 Q05BA5_MOUSE (1-1353): 1.49e-167: 540: 100.00		NR1I2_MOUSE (19-462): 3.79e-80: 257: 22.72
+	Mm
		60470 A5D6Q2_MOUSE (1-1353): 4.78e-168: 540: 100.00		NR1I2_MOUSE (19-462): 3.79e-80: 257: 22.72
+	Hs
		846431 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		RORG_HUMAN (9-465): 3.15e-108: 332: 46.28
+	Hs
		130340 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		NR5A2_HUMAN (14-457): 2.22e-100: 312: 23.39
+	Hs
		874407 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		NR1H2_HUMAN (7-464): 5.27e-88: 278: 19.44
+	Hs
		510000 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		VDR_HUMAN (1-464): 4.27e-86: 272: 22.34
+	Hs
		265886 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		NR1I2_HUMAN (2-463): 9.17e-84: 266: 22.29
+	Hs
		740635 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		PPARG_HUMAN (4-461): 3.21e-82: 264: 24.46
+	Hs
		975487 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		PPARD_HUMAN (16-461): 8.72e-82: 261: 23.78
+	Hs
		723182 HIF1A_HUMAN (2-704): 1.09e-102: 348: 14.29		RORA_HUMAN (6-464): 9.48e-115: 349: 61.61
+	Hs
		992458 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		PPARA_HUMAN (6-461): 3.8e-73: 239: 22.39
+	Mm
		846435 HIF1A_MOUSE (2-679): 1.23e-106: 359: 14.37		RORG_MOUSE (9-465): 9.58e-104: 320: 45.86
+	Hs
		130327 NCOA2_HUMAN (1-1344): 2.67e-93: 333: 37.83		NR5A2_HUMAN (14-457): 2.22e-100: 312: 23.39
+	Hs
		500381 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		RARB_HUMAN (20-116): 4.33e-45: 165: 51.55
+	Hs
		530818 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		RARG_HUMAN (20-95): 4.38e-44: 162: 63.16
+	Hs
		488043 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		RARA_HUMAN (20-95): 1e-42: 159: 61.84
+	Hs
		265869 NCOA2_HUMAN (1-1344): 2.67e-93: 333: 37.83		NR1I2_HUMAN (2-463): 9.17e-84: 266: 22.29
+	Hs
		587212 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		RXRA_HUMAN (21-102): 5.89e-28: 117: 57.32
+	Hs
		490120 NCOA3_HUMAN (1-1353): 1.22e-136: 456: 80.40		COT1_HUMAN (19-100): 2.43e-27: 115: 59.76