HitPredict

Interactor 1: HSP74 (P22202)
Heat shock protein SSA4
Gene: SSA4

Interactor 2: APJ1 (P53940)
J domain-containing protein APJ1
Gene: APJ1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	17892321, 32492414
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042026 - protein refolding GO:0051082 - unfolded protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 642 Sc			1 528
+	Hs
		681341 HS71L_HUMAN (2-642): 0: 962: 71.30		DNJA1_HUMAN (1-484): 1.22e-126: 377: 26.88
+	Hs
		564015 HSP76_HUMAN (4-642): 0: 954: 71.67		DNJA1_HUMAN (1-484): 1.22e-126: 377: 26.88
+	Hs
		503527 HSP7C_HUMAN (2-642): 0: 953: 73.72		DNJA1_HUMAN (1-484): 1.22e-126: 377: 26.88
+	Hs
		564136 HSP76_HUMAN (4-642): 0: 954: 71.67		DNJA4_HUMAN (1-470): 4.76e-123: 368: 27.37
+	Hs
		243312 HS71L_HUMAN (2-642): 0: 962: 71.30		DNJA2_HUMAN (2-455): 2.4e-113: 343: 27.89
+	Hs
		714049 HS71L_HUMAN (2-642): 0: 962: 71.30		DNJA3_HUMAN (5-467): 1.5e-111: 341: 21.14
+	Hs
		243284 HSP76_HUMAN (4-642): 0: 954: 71.67		DNJA2_HUMAN (2-455): 2.4e-113: 343: 27.89
+	Hs
		243275 HSP7C_HUMAN (2-642): 0: 953: 73.72		DNJA2_HUMAN (2-455): 2.4e-113: 343: 27.89
+	Hs
		504564 HSP7C_HUMAN (2-642): 0: 953: 73.72		DNJA3_HUMAN (5-467): 1.5e-111: 341: 21.14
+	Sc
		493305 HSP72_YEAST (1-642): 0: 947: 81.62		MAS5_YEAST (1-461): 1.1e-113: 344: 31.93
+	Hs
		714088 HS71L_HUMAN (2-642): 0: 962: 71.30		DNJB4_HUMAN (5-428): 2.53e-97: 300: 21.46
+	Hs
		279280 HS71L_HUMAN (2-642): 0: 962: 71.30		DNJB5_HUMAN (5-427): 3.38e-96: 297: 22.70
+	Hs
		636256 HS71L_HUMAN (2-642): 0: 962: 71.30		DNJB1_HUMAN (5-427): 1.1e-95: 295: 21.93
+	Hs
		564203 HSP76_HUMAN (4-642): 0: 954: 71.67		DNJB4_HUMAN (5-428): 2.53e-97: 300: 21.46
+	Hs
		504901 HSP7C_HUMAN (2-642): 0: 953: 73.72		DNJB4_HUMAN (5-428): 2.53e-97: 300: 21.46
+	Hs
		279274 HSP76_HUMAN (4-642): 0: 954: 71.67		DNJB5_HUMAN (5-427): 3.38e-96: 297: 22.70
+	Hs
		279272 HSP7C_HUMAN (2-642): 0: 953: 73.72		DNJB5_HUMAN (5-427): 3.38e-96: 297: 22.70
+	Hs
		564008 HSP76_HUMAN (4-642): 0: 954: 71.67		DNJB1_HUMAN (5-427): 1.1e-95: 295: 21.93
+	Hs
		503463 HSP7C_HUMAN (2-642): 0: 953: 73.72		DNJB1_HUMAN (5-427): 1.1e-95: 295: 21.93
+	Sc
		493271 HSP72_YEAST (1-642): 0: 947: 81.62		SCJ1_YEAST (6-425): 6.87e-96: 297: 24.59