HitPredict

Interactor 1: VATE (P22203)
V-type proton ATPase subunit E (V-ATPase subunit E) (V-ATPase 27 kDa subunit) (Vacuolar proton pump subunit E)
Gene: VMA4

Interactor 2: VATC (P31412)
V-type proton ATPase subunit C (V-ATPase subunit C) (V-ATPase 42 kDa subunit) (Vacuolar proton pump subunit C)
Gene: VMA5

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.956

The method score is based on:

Property	Details
Experiments	16429126, 20446876, 16774922, 15751969, 33895134, 37968396, 23142977
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, tandem affinity purification
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	V-ATPase_C~vATP-synt_E
Common GO terms	GO:0000139 - Golgi membrane GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain GO:0000329 - fungal-type vacuole membrane GO:0007035 - vacuolar acidification GO:0016471 - vacuolar proton-transporting V-type ATPase complex and 5 others more... GO:0033176 - proton-transporting V-type ATPase complex GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:0048388 - endosomal lumen acidification GO:0061795 - Golgi lumen acidification GO:1902600 - proton transmembrane transport
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	233
Sc

1	392

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024