HitPredict

Interactor 1: VATE (P22203)
V-type proton ATPase subunit E (V-ATPase subunit E) (V-ATPase 27 kDa subunit) (Vacuolar proton pump subunit E)
Gene: VMA4

Interactor 2: VPP1 (P32563)
V-type proton ATPase subunit a, vacuolar isoform (V-ATPase a 1 subunit) (V-ATPase 95 kDa subunit) (Vacuolar pH protein 1) (Vacuolar proton pump a subunit) (Vacuolar proton translocating ATPase subunit a 1)
Gene: VPH1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.918

Property	Details
Experiments	11592965, 19081055, 18662668, 37968396, 23071676
Identification Methods	coimmunoprecipitation, anti tag coimmunoprecipitation, affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	V_ATPase_I~vATP-synt_E
Common GO terms	GO:0000329 - fungal-type vacuole membrane GO:0007035 - vacuolar acidification GO:0016471 - vacuolar proton-transporting V-type ATPase complex GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:1902600 - proton transmembrane transport
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 233 Sc			1 840
+	Hs
		736122 VATE1_HUMAN (7-233): 3.16e-96: 282: 33.48		VPP1_HUMAN (8-824): 0: 1220: 40.21
+	Hs
		736128 VATE1_HUMAN (7-233): 3.16e-96: 282: 33.48		VPP4_HUMAN (7-824): 0: 1198: 36.82
+	Hs
		736135 VATE1_HUMAN (7-233): 3.16e-96: 282: 33.48		VPP2_HUMAN (7-822): 0: 1152: 36.59
+	Hs
		736113 VATE1_HUMAN (7-233): 3.16e-96: 282: 33.48		VPP3_HUMAN (7-826): 0: 1034: 35.75
+	Sc
		605423 VATE_YEAST (1-233): 1.82e-83: 249: 100.00		VPP2_YEAST (4-824): 0: 987: 49.10