HitPredict

Interactor 1: SEC22 (P22214)
Protein transport protein SEC22 (Suppressor of loss of YPT1 protein 2)
Gene: SEC22

Interactor 2: PEP12 (P32854)
Syntaxin PEP12 (Carboxypeptidase Y-deficient protein 12) (Vacuolar protein sorting-associated protein 6) (Vacuolar protein-targeting protein 13)
Gene: PEP12

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	24589832
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0000139 - Golgi membrane GO:0005484 - SNAP receptor activity GO:0005794 - Golgi apparatus GO:0006886 - intracellular protein transport GO:0006906 - vesicle fusion and 1 others more... GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 214 Sc			1 288
+	At
		955702 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SYP22_ARATH (1-275): 1.38e-55: 182: 23.19
+	Hs
		263179 SC22B_HUMAN (1-211): 3.83e-76: 229: 35.65		STX2_HUMAN (14-288): 1.79e-55: 182: 20.14
+	At
		1352985 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SYP42_ARATH (23-287): 1e-48: 166: 17.98
+	At
		249598 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SYP41_ARATH (23-287): 6.95e-49: 166: 17.23
+	At
		1352876 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SYP43_ARATH (23-287): 3.39e-47: 162: 17.36
+	At
		812702 VA722_ARATH (1-197): 3.23e-82: 245: 16.42		SY121_ARATH (8-269): 3.2e-46: 160: 18.82
+	At
		1352937 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SY122_ARATH (1-269): 1.96e-46: 160: 19.12
+	At
		1378372 VA721_ARATH (1-197): 1.8e-81: 243: 16.92		SY121_ARATH (8-269): 3.2e-46: 160: 18.82
+	Mm
		139056 SC22B_MOUSE (1-211): 3.83e-76: 229: 35.65		STX1A_MOUSE (1-287): 4.97e-52: 173: 17.59
+	Hs
		263248 SC22B_HUMAN (1-211): 3.83e-76: 229: 35.65		STX1A_HUMAN (28-287): 1.67e-51: 172: 19.01
+	At
		955681 VA713_ARATH (1-210): 3.21e-69: 212: 16.11		SYP22_ARATH (1-275): 1.38e-55: 182: 23.19
+	Rn
		996534 SC22B_RAT (1-211): 3.83e-76: 229: 35.65		STX5_RAT (2-270): 1.15e-46: 161: 13.55
+	Dm
		115811 M9PGI6_DROME (1-211): 2.83e-67: 207: 30.09		Q7K0X9_DROME (25-286): 3.76e-54: 178: 23.88
+	Hs
		263226 SC22B_HUMAN (1-211): 3.83e-76: 229: 35.65		STX4_HUMAN (31-288): 4.63e-45: 156: 18.15
+	Hs
		178331 SC22B_HUMAN (1-211): 3.83e-76: 229: 35.65		STX7_HUMAN (25-286): 2.11e-45: 155: 21.29
+	Hs
		263229 SC22B_HUMAN (1-211): 3.83e-76: 229: 35.65		STX5_HUMAN (2-270): 2.69e-44: 155: 13.92
+	Hs
		263279 SC22B_HUMAN (1-211): 3.83e-76: 229: 35.65		STX12_HUMAN (17-274): 3.12e-45: 155: 20.91
+	Dm
		115804 M9PGI6_DROME (1-211): 2.83e-67: 207: 30.09		STX5_DROME (8-271): 2.18e-47: 166: 13.70
+	Dm
		115805 M9PGI6_DROME (1-211): 2.83e-67: 207: 30.09		STX1A_DROME (27-286): 2.2e-49: 166: 19.77
+	Dm
		115838 M9PGI6_DROME (1-211): 2.83e-67: 207: 30.09		Q9VR90_DROME (22-280): 5.01e-32: 123: 18.15