HitPredict

Interactor 1: RAD53 (P22216)
Serine/threonine-protein kinase RAD53 (EC 2.7.12.1) (CHEK2 homolog) (Serine-protein kinase 1)
Gene: RAD53

Interactor 2: RAD53 (P22216)
Serine/threonine-protein kinase RAD53 (EC 2.7.12.1) (CHEK2 homolog) (Serine-protein kinase 1)
Gene: RAD53

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.974

The method score is based on:

Property Details
Experiments 16751663, 24815189, 12917350, 28858528, 18239457, 20061370, 37766847, 22323608, 21179020
Identification Methods enzymatic study, pull down, x-ray crystallography, affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FHA~FHA, FHA~Pkinase, Pkinase~Pkinase
Common GO terms GO:0000077 - DNA damage checkpoint signaling
GO:0003688 - DNA replication origin binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calmodulin-dependent protein kinase activity
and 18 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 821
Sc

1 821
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ At
+ At
+ At
+ Gm
+ Hs
+ Sp
+ Hs
+ Hs
+ At
+ At
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024